The Function of Chromatin is varied and include ensuring the stability of DNA, affecting gene expression, and chromosome replication
Latest Function of Chromatin Publications:
The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. The PEV-modifying winged-helix/forkhead domain transcription factor JUMU ... Hofmann A, Brunner M, Schwendemann A, Strodicke M, Karberg S, Klebes A, Saumweber H, Korge G,http://dx.doi.org/10.1007/s10577-010-9118-y Chromosome Res. 2010 Mar 6.
The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer. PURPOSE: Ascorbic acid is an essential micronutrient and is considered to ... Ullah MF, Khan HY, Zubair H, Shamim U, Hadi SM,http://dx.doi.org/10.1007/s00280-010-1290-4 Cancer Chemother Pharmacol. 2010 Mar 6.
Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing. Carbonylation of proteins is irreversible oxidative damage that increases ... Orlandi I, Bettiga M, Alberghina L, Nystrom T, Vai M,http://dx.doi.org/10.1016/j.bbamcr.2010.02.009 Biochim Biophys Acta. 2010 Mar 4.
A paucity of heterochromatin at functional human neocentromeres. ABSTRACT: BACKGROUND: Centromeres are responsible for the proper ... Alonso A, Hasson D, Cheung F, Warburton PE,http://dx.doi.org/10.1186/1756-8935-3-6 Epigenetics Chromatin. 2010 Mar 8;3(1):6.
Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. Abstract Background. DNA and chromatin modifications are critical ... Obier N, Uhlemann CF, Muller AM,http://dx.doi.org/10.3109/14653240903580254 Cytotherapy. 2010 Mar 9.
Redox Control Systems in the Nucleus: Mechanisms and Functions. Abstract Proteins with oxidizable thiols are essential to many functions ... Go YM, Jones DP,http://dx.doi.org/10.1089/ars.2009.3021 Antioxid Redox Signal. 2010 Mar 8.
CREBBP Re-arrangements affect protein function and lead to aberrant neuronal differentiation. Biallelic inactivation of the CREB-binding protein (CREBBP) a ... Sharma N, Jadhav SP, Bapat SA,http://dx.doi.org/10.1016/j.diff.2010.02.001 Differentiation. 2010 Mar 5.
The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression. AIMS: Cytochrome P4502C19 (CYP2C19) is an important enzyme involved in the ... Mwinyi J, Hofmann Y, Pedersen RS, Nekvindova J, Cavaco I, Mkrtchian S, Ingelman-Sundberg M,http://dx.doi.org/10.1016/j.lfs.2010.02.021 Life Sci. 2010 Mar 3.
Building centromeres: home sweet home or a nomadic existence? Centromere assembly and propagation is governed by genetic and epigenetic ... Buscaino A, Allshire R, Pidoux A,http://dx.doi.org/10.1016/j.gde.2010.01.006 Curr Opin Genet Dev. 2010 Mar 3.
Assembly dynamics of PML nuclear bodies in living cells. ABSTRACT: The mammalian cell nucleus contains a variety of organelles or ... Brand P, Lenser T, Hemmerich P,http://dx.doi.org/10.1186/1757-5036-3-3 PMC Biophys. 2010 Mar 5;3(1):3.
Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development. MeCP2 plays a critical role in interpreting epigenetic signatures that ... Alvarez-Saavedra M, Carrasco L, Sura-Trueba S, Demarchi Aiello V, Walz K, Xavier Neto J, Young JI,http://dx.doi.org/10.1093/hmg/ddq096 Hum Mol Genet. 2010 Mar 4.
Symposium 2: Modern approaches to nutritional research challenges Nutritional developmental epigenomics: immediate and long-lasting effects. The phenotype of an individual is the result of complex interactions ... Attig L, Gabory A, Junien C,http://dx.doi.org/10.1017/S002966511000008X Proc Nutr Soc. 2010 Mar 5:1-11.
A Rat Monoclonal Antibody Against the Chromatin Remodeling Factor CHD5. CHD5 (chromodomain/helicase/DNA-binding protein 5) is a member of the CHD ... Yoshimura S, Yoshimi T, Ohkawa Y, Azuma M, Tachibana T,http://dx.doi.org/10.1089/hyb.2009.0069 Hybridoma (Larchmt). 2010 Feb;29(1):63-6.
RUNX2 Transcription Factor Regulates Gene Expression in Luteinizing Granulosa Cells of Rat Ovaries. The LH surge promotes terminal differentiation of follicular cells to ... Park ES, Lind AK, Dahm-Kahler P, Brannstrom M, Carletti MZ, Christenson LK, Curry TE Jr, Jo M,http://dx.doi.org/10.1210/me.2009-0392 Mol Endocrinol. 2010 Mar 2.
Statistics of protein-DNA binding and the total number of binding sites for a transcription factor in the mammalian genome. BACKGROUND: Transcription factor (TF)-DNA binding loci are explored by ... Kuznetsov VA, Singh O, Jenjaroenpun P,http://dx.doi.org/10.1186/1471-2164-11-S1-S12 BMC Genomics. 2010 Feb 10;11 Suppl 1:S12.