Chromatin has a major role in gene regulation, the structure of chromatin its self is regulated primarily through acylation and methylation
Latest Chromatin Modification Publications:
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Multipotent progenitor cells of the cerebral cortex balance self-renewal ... Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ,http://dx.doi.org/10.1073/pnas.1002530107 Proc Natl Acad Sci U S A. 2010 Aug 23.
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. The number of mouse mutants and strains with neural tube defects (NTDs) ... Harris MJ, Juriloff DM,http://dx.doi.org/10.1002/bdra.20676 Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):653-69.
Proteomic investigation of epigenetics in neuropsychiatric disorders: A missing link between genetics and behavior? Neuropsychiatric disorders affect a large segment of the human population ... Plazas-Mayorca MD, Vrana KE,http://dx.doi.org/10.1021/pr100463y J Proteome Res. 2010 Aug 25.
Towards a better understanding of nuclear processes based on proteomics. The complex structural and functional organisation of the brain warrants ... Tweedie-Cullen RY, Mansuy IM,http://dx.doi.org/10.1007/s00726-010-0723-z Amino Acids. 2010 Aug 22.
Variable Numbers of Tandem Repeats in Plasmodium falciparum Genes. Genome variation studies in Plasmodium falciparum have focused on SNPs ... Tan JC, Tan A, Checkley L, Honsa CM, Ferdig MT,http://dx.doi.org/10.1007/s00239-010-9381-8 J Mol Evol. 2010 Aug 22.
Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells. In response to a variety of extracellular ligands, the STAT (signal ... Buro LJ, Shah S, Henriksen MA,http://dx.doi.org/10.3791/2053 J Vis Exp. 2010 Jul 29;(41). pii: 2053. doi: 10.3791/2053.
Targeting poly(ADP-ribose) polymerase activity for cancer therapy. Poly(ADP-ribosyl)ation is a ubiquitous protein modification found in ... Megnin-Chanet F, Bollet MA, Hall J,http://dx.doi.org/10.1007/s00018-010-0490-8 Cell Mol Life Sci. 2010 Aug 20.
Epigenetic Regulation of Thy-1 by Histone Deacetylase Inhibitor in Rat Lung Fibroblasts. Thy-1 is a cell surface glycoprotein present on normal lung fibroblasts ... Sanders YY, Tollefsbol TO, Varisco BM, Hagood JS,http://dx.doi.org/10.1165/rcmb.2010-0154OC Am J Respir Cell Mol Biol. 2010 Aug 19.
Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. ABSTRACT: BACKGROUND: Numerous epidemiological studies have documented ... Stefanou N, Papanikolaou V, Furukawa Y, Nakamura Y, Tsezou A,http://dx.doi.org/10.1186/1471-2407-10-442 BMC Cancer. 2010 Aug 19;10(1):442.
DNA Methylation Regulates Cocaine-Induced Behavioral Sensitization in Mice. The behavioral sensitization produced by repeated cocaine treatment ... Anier K, Malinovskaja K, Aonurm-Helm A, Zharkovsky A, Kalda A,http://dx.doi.org/10.1038/npp.2010.128 Neuropsychopharmacology. 2010 Aug 18.
Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. ABSTRACT: BACKGROUND: Modifications of DNA and histones in various ... Yang F, Zhang L, Li J, Huang J, Wen R, Ma L, Zhou D, Li L,http://dx.doi.org/10.1186/1471-2229-10-178 BMC Plant Biol. 2010 Aug 18;10(1):178.
Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination. Eukaryotic chromatin is regulated by chromatin factors such as histone ... Endo H, Kawashima S, Sato L, Lai MS, Enomoto T, Seki M, Horikoshi M,http://dx.doi.org/10.1111/j.1365-2443.2010.01435.x Genes Cells. 2010 Sep 1;15(9):945-58. Epub 2010 Aug 16.
Polycomb proteins in hematologic malignancies. The Polycomb group (PcG) of proteins is a major mechanism of epigenetic ... Martin-Perez D, Piris MA, Sanchez-Beato M,http://dx.doi.org/10.1182/blood-2010-05-267096 Blood. 2010 Aug 17.
Characterisation of a novel WDR5 binding site that recruits RbBP5 through a conserved motif and enhances methylation of H3K4 by MLL1. Histone modification is well established as a fundamental mechanism ... Odho Z, Southall SM, Wilson JR,http://dx.doi.org/10.1074/jbc.M110.159921 J Biol Chem. 2010 Aug 17.
The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells. Abstract c-MYC is a well known nuclear oncoprotein having multiple ... Bhandari DR, Seo KW, Jung JW, Kim HS, Yang SR, Kang SK, Kang KS,http://dx.doi.org/10.1111/j.1582-4934.2010.01144.x J Cell Mol Med. 2010 Aug 16.